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The Modulated Role of Toxoplasma Gondii on Eosinophils in Psychiatric Disorders after Cannabis Cessation

Version 1
: Received: 8 September 2023 / Approved: 15 September 2023 / Online: 18 September 2023 (13:25:31 CEST)

How to cite:
Roméo, B.; Lestra, V.; Martelli, C.; Amirouche, A.; Benyamina, A.; Hamdani, N. The Modulated Role of Toxoplasma Gondii on Eosinophils in Psychiatric Disorders after Cannabis Cessation. Preprints 2023, 2023091091. https://doi.org/10.20944/preprints202309.1091.v1

Roméo, B.; Lestra, V.; Martelli, C.; Amirouche, A.; Benyamina, A.; Hamdani, N. The Modulated Role of Toxoplasma Gondii on Eosinophils in Psychiatric Disorders after Cannabis Cessation. Preprints 2023, 2023091091. https://doi.org/10.20944/preprints202309.1091.v1

MDPI and ACS Style

Roméo, B.; Lestra, V.; Martelli, C.; Amirouche, A.; Benyamina, A.; Hamdani, N. The Modulated Role of Toxoplasma Gondii on Eosinophils in Psychiatric Disorders after Cannabis Cessation. Preprints 2023, 2023091091. https://doi.org/10.20944/preprints202309.1091.v1

APA Style

Roméo, B., Lestra, V., Martelli, C., Amirouche, A., Benyamina, A., & Hamdani, N. (2023). The Modulated Role of Toxoplasma Gondii on Eosinophils in Psychiatric Disorders after Cannabis Cessation. Preprints. https://doi.org/10.20944/preprints202309.1091.v1

Chicago/Turabian Style

Roméo, B., Amine Benyamina and Nora Hamdani. 2023 “The Modulated Role of Toxoplasma Gondii on Eosinophils in Psychiatric Disorders after Cannabis Cessation” Preprints. https://doi.org/10.20944/preprints202309.1091.v1

The aim of our study was to evaluate the impact of T. gondii status on eosinophils count (PNE), eosinophil to lymphocyte ratio (ELR) and eosinophil to neutrophil to lymphocytes ratio (ENLR) before and after can-nabis cessation in patients with psychiatric disorders. One hundred and eighty-eight patients were includ-ed in the study. T. gondii, PNE, ELR, ENLR, and urinary cannabis were measured at baseline and after 4 weeks of cannabis cessation. Highest PNE (p = .02), ELR (p = .03) and ENLR levels (p = .031) and highest increase of PNE (p = .044), and ENLR (p = .036) levels were found in patients after cannabis cessation only in the Toxo+ group. At four weeks, significant interactions between cannabis and T. gondii status for PNE (p = .038), and for ENLR (p = .043) levels were found, as well as for the evolution between baseline and 4 weeks for ENLR level (p = .049). After cannabis cessation, we found a positive correlation between negative symptoms and PNE levels at 4 weeks in the Toxo+ group. This study shows that the increase of inflammation after cannabis cessation might be modulated by T. gondii seropositivity status in patient after cannabis cessation.

Medicine and Pharmacology, Psychiatry and Mental Health

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The Modulated Role of Toxoplasma Gondii on Eosinophils in Psychiatric Disorders after Cannabis Cessation

The Modulated Role of Toxoplasma Gondii on Eosinophils in Psychiatric Disorders after Cannabis Cessation

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